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根據美國《紐約時報》報導,將近百分之七十美國消費者同意將「生物科技」應用於農業生產和食品製造,但是,當被詢及能否接受「基因改造食品」時,卻有三分之二受訪者表示「無法接受」。西方十八世紀啟蒙時期的思想家早已警覺,理性的科學知識發展固然可以提升人類福祉,但也不可避免帶來許多苦果與問題;上述矛盾的愛懼情結正反映了這個兩難的抉擇。生物科技要如何才能服務社會而非危害社會?請來聽聽楊寧蓀教授的生物科技「第三條路」。 |
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在病死豬的恐慌陰影中,你還記得1997年開始肆虐臺灣、令人談豬色變的口蹄疫嗎?我們的講員楊寧蓀曾帶領研究團隊建立口蹄疫病毒和豬繁殖與呼吸道癥候羣的DNA疫苗研究系統,以及口蹄疫病毒的攻毒模式,對於消滅並預防口蹄疫有著重大的貢獻。不僅如此,楊寧蓀也積極從事各種以生農物製造疫苗的研發,可算是生科界的前瞻人物。 |
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學經歷 : 1974美國密西根州立大學生化遺傳學程博士 1974~1975ROCHE分子生物學學院分生學博士後研究 1976~1981密西根癌癥研究中心病毒和腫瘤基因學研究室研究員 1981~1982密西根癌癥研究中心癌癥生物化學研究室負責人 1982~1997遺傳基因公司Agracetus 資深科學家及研究員 1990~2000威斯康辛州大學醫學院副教授 1991~1993Agracetus 哺乳動物遺傳學研究計畫領導人 1993~1997Agracetus 癌癥基因療法研究主管 1997~2000威斯康辛州大學綜合癌癥研究中心主要研究員 1997~中央研究院生物農業科學研究所籌備處特聘研究員兼主任 |
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代表著作 : Yang, N.-S., Manning, R.F. and Gage, L.P. (1976) The blocked and methylated 5' terminal sequence of a specific cellular messenger: The mRNA for silk fibroin of Bombyx mori. Cell 7: 339-347. Yang, N.-S.* and Russell, D. (1990) Maize sucrose synthase-1 promoter directs phloem cell-specific expression of GUS gene in transgenic tobacco plants. Proc. Natl. Acad. Sci. USA 87: 4144-4148. Yang, N.-S.*, Burkholder, J., Roberts, B., Martinell, B. and McCabe, D. (1990) In vivo and In vitro gene transfer to mammalian somatic cells by particle bombardment. Proc. Natl. Acad. Sci. USA 87: 9568-9572. Cheng, L., Ziegelhoffer, P.R., and Yang, N.-S.* (1993) In vivo promoter activity and transgene expression in mammalian somatic tissues evaluated by using particle bombardment. Proc. Natl. Acad. Sci. USA. 90: 4455-4459. Sun, W.H., Burkholder, J.K., Sun, J., Culp, J., Turner, J., Lu, X.G., Pugh, T.D., Ershler, W.B., and Yang, N.-S.* (1995) In vivo cytokine gene transfer by gene gun reduces tumor growth in mice. Proc. Natl. Acad. Sci. USA. 92: 2889-2893. Yang, N.-S.* and Sun, W.H. (1995) Gene gun and other non-viral approaches for cancer gene therapy. Nature Medicine 1: 481-483. Cheng, L., Sun, J., Pretlow, T., Culp, J., andYang, N.-S.* (1996) CWR22 xenograft as an ex vivo human tumor model for prostate cancer gene therapy. J. Natl. Cancer Inst.88: 607-611. Ye, Z. Q., Qiu, P., Burkholder, J. K., Turner, J. G., Culp, J., Roberts, T., Shahidi, N.T., andYang, N.-S.* (1998). Cytokine transgene expression and promoter usage in primary CD34+ cells using particle-mediated gene delivery. Human Gene Therapy 9: 2197-2205. Oshikawa, K., Shi, F., Rakhmilevich, A.L., Sondel, P. M., Mahvi, D. M.,Yang, N.-S.* (1999). Synergistic inhibition of tumor growth in a murine mammary adenocarcinoma model by combinational gene therapy using IL-12, pro-IL-18, and IL-1 beta converting enzyme cDNA. Proc. Natl. Acad. Sci. USA 96: 13351-13356. Yang, N.-S.*, Wang, J.-H., and Turner, J. (2004) Molecular strategies for improving cytokine transgene expression in normal and malignant tissues. Gene Ther. Jan 11(1): 100-8. Staniforth V., Wang S.-Y., Shyur L.-F.,Yang, N.-S.* (2004) Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activition of human TNF-a promoter in vivo. J. Biol. Chem. Feb 13;279(7):5877-5885 |
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